In vivo Anthelmintic Activity of Medicinal Plant Asparagus racemosus Against Larva of Fasciola gigantica

Trematode infections are causes zoonotic disease by Fasciola hepatica and F. gigantica among cattle and human. The control of fascioliasis by treatment of sporocyst, redia and cercaria larva in in vivo which can break the life cycle and check the zoonotic disease. The present study was designed for treatment of F. gigantica larva in host snail Lymnaea acuminata in in vivo at different exposures. The dried root powder of Asparagus racemosus and their different organic extract (ether, chloroform, methanol, acetone and ethanol) and column purified fractions was observed up to 8h at different concentration against Fasciola larva. In vivo mortality of larva was observed at 2h, 4h, 6h and 8h of treatment of infected snails at different concentration. The dried root powder of A. racemosus were more effective (2h LC50 71.39 mg/l and 8h LC50 63.22 mg/l) against cercaria larvae. The 8h LC50 of ethanol extract against sporocyst, redia and cercaria was observed 51.90, 48.05 and 49.76 mg/l, respectively. Among all organic extracts, ethanolic extract was more effective than other extract. The LC50 of 8h exposure of column purified fraction of A. racemosus was 50.37, 45.92 and 46.30 mg/l against sporocyst, redia and cercaria, respectively.

A. K. Vishwakarma1 and Pradeep Kumar*2 Click here to download file

Research Article | Published online : 19-Apr-2021