Synthesis and Characterization of Transfersomes and Evaluation of Entrapment and Unentrapment Efficiency of the Phenol Extracted from Camellia sinensis with the Physical and Chemical Stability of Transdermal Patch

Camellia sinensis (green tea) is widely known for its medicinal quality in treating ailments and acts as an excellent antioxidant and stimulator for decades. It is rich in phyto constituents and has high amount of active compounds like phenols, polyphenols and caffeine. Polyphenols found in Camellia sinensis (green tea) exhibits many beneficial biochemical effects in vitro and in vivo. Nano biopharmaceutics is the recent technology, which is used for drug delivery system. Transdermal is an application process by which, skin permeation enhancers promotes skin fluidity and ‘Nano-porosity’ which increase the capability of low molecular weight lipid- based vesicles to cross the skin. Using different lipid mediated carriers as nanovesicle loaded with desired effective drugs to the targeted sites in treating diseases has been an effective method in the recent past. The present study focuses on extraction and quantification of phenolic content present in the green tea leaves extract by means of physical and chemical stability, λ max determination, Entrapment efficiency and SEM analysis. Optimizing the effective Nanovesicle tranfersomes is done by various process variables like Soy lecithin with Tween 80 (1:1 and 1:2 ratios) and Cholesterol with span 60. The entrapment efficiency is found to be high at Soy lecithin with Tween 80 (1:1 ratio) 6000 rpm at room temperature. Thus, the present finding infers that the transferosomes entrapped with Green tea leaf extract would be a promising approach in preparing transdermal patches that would treat many diseases and be an efficacious targeted drug delivery system.

Arunsagayaraj Irudayasamy1, Janaky Ranjithkumar2, Sivaelango Gopal3 and Durga Devi Munireddy*4 Click here to download file

Research Article | Published online : 23-Sep-2021