Synthesis, Characterization and Anti-bacterial Studies of 4-(arylsulfonyl)methyl-2H-Chromene Derivatives

A series of novel 4-((arylsulfonyl)methyl)-2H-chromen-2-one has been synthesized by Pechmann condensation of ethyl 3-oxo-4-(arylsulfonyl)butanoate 7, various phenol derivatives using AlCl3 as a Lewis catalyst in the presence of Nitro benzene at 100 - 130⁰C. The prepared compounds were screened for anti-bacterial activity studies Many of the compounds shown remarkable anti-bacterial activity against the tested organisms. A series of novel 4-((arylsulfonyl)methyl)-2H-chromen-2-one has been synthesized by Pechmann condensation of ethyl 3-oxo-4-(arylsulfonyl)butanoate 7, various phenol derivatives using AlCl3 as a Lewis catalyst in the presence of Nitro benzene at 100 - 130⁰C. The prepared compounds were screened for anti-bacterial activity studies Many of the compounds shown remarkable anti-bacterial activity against the tested organisms. A series of novel 4-((arylsulfonyl)methyl)-2H-chromen-2-one has been synthesized by Pechmann condensation of ethyl 3-oxo-4-(arylsulfonyl)butanoate 7, various phenol derivatives using AlCl3 as a Lewis catalyst in the presence of Nitro benzene at 100 - 130⁰C. The prepared compounds were screened for anti-bacterial activity studies Many of the compounds shown remarkable anti-bacterial activity against the tested organisms.

P. S. HARIKRISHNAN*1 Click here to download file

Research Article | Published online : 31-Dec-2023