Assessment of Antidiabetic Potential of Ethanolic Leaves Extracts from Mangifera indica, Cynodon dactylon and Aegle marmelos in Alloxan-Induced Diabetic Mice: A Combined Biochemical and Histopathological Analysis

Diabetes mellitus is a prevalent global health issue, often associated with oxidative stress and insulin resistance. This study investigated the antidiabetic effects of ethanolic extracts from Aegle marmelos, Cynodon dactylon and Mangifera indica on alloxan-induced diabetic mice. Diabetes was induced in adult and aged mice using alloxan monohydrate (150 mg/kg body weight), followed by oral administration of plant extracts (200 mg/kg body weight) for 20 days. Treatment significantly reduced fasting blood glucose levels in both adult and aged diabetic mice. Additionally, there was a marked decrease in lipid peroxidation (MDA) levels and an increase in superoxide dismutase (SOD) activity, indicating enhanced antioxidant defense. Histopathological analysis revealed partial restoration of β-cell morphology, improved islet architecture, and reduced inflammatory infiltration. These findings suggest that the ethanolic extracts of Mangifera indica, Cynodon dactylon and Aegle marmelos possess potent antidiabetic effects by reducing oxidative stress, boosting antioxidant enzyme activity, and promoting pancreatic β-cell regeneration. This study underscores the therapeutic potential of these medicinal plants as alternatives or supplements to conventional antidiabetic treatments.

T. A. GANGAVANE*1 and R. D. BODARE2 Click here to download file

Research Article | Published online : 31-Dec-2023